Drug General Information
Drug ID	D02FEV
Former ID	DIB014340
Drug Name	S-8921
Drug Type	Small molecular drug
Indication	Hyperlipidaemia [ICD9: 272.0-272.4; ICD10:E78]		Phase 2	[534690]
Company	Shionogi & Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C30H36O9
Canonical SMILES	c1(c(c(c2c(c1O)cc(c(c2OC)OC)OC)c1cc(c(cc1)OC)OC)C(=O)OC<br />)C(=O)CC(CC)CC
CAS Number	CAS 151165-96-7
PubChem Compound ID	153965
Target and Pathway
Target(s)	Ileal bile acid transfer	Target Info	Inhibitor	[534690]
KEGG Pathway	Bile secretion
Reactome	Recycling of bile acids and salts
WikiPathways	Bile acid and bile salt metabolism
References
Ref 534690	Inhibition of ileal Na+/bile acid cotransporter by S-8921 reduces serum cholesterol and prevents atherosclerosis in rabbits. Arterioscler Thromb Vasc Biol. 1998 Aug;18(8):1304-11.
Ref 534690	Inhibition of ileal Na+/bile acid cotransporter by S-8921 reduces serum cholesterol and prevents atherosclerosis in rabbits. Arterioscler Thromb Vasc Biol. 1998 Aug;18(8):1304-11.

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