Drug General Information
Drug ID	D0Z7AN
Former ID	DIB008489
Drug Name	Ro-19-8022
Drug Type	Small molecular drug
Indication	Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42]		Terminated	[544933]
Company	Roche Holding AG
Structure		Download 2D MOL 3D MOL
Formula	C25H21ClN2O3
Canonical SMILES	c1(c2n(c(=O)c(c1)c1ccccc1)ccc1c2cc(cc1)Cl)C(=O)N1[C@@H]<br />(CO)CCC1
CAS Number	CAS 104604-66-2
PubChem Compound ID	3035058
Target and Pathway
Target(s)	GABA A receptor	Target Info	Modulator
KEGG Pathway	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
	GABAergic synapse
	Morphine addiction
	Nicotine addiction
Reactome	Ligand-gated ion channel transport
	GABA A receptor activation
WikiPathways	SIDS Susceptibility Pathways
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transport
References
Ref 544933	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001584)

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