Drug Information

Drug General Information
Drug ID
D0V0NL
Former ID
DNC000203
Drug Name
Aminoguanidine
Drug Type
Small molecular drug
Indication Discovery agent Phase 1 [468198], [521693]
Structure
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2D MOL

3D MOL
Formula
CH6N4
InChI
InChI=1S/CH6N4/c2-1(3)5-4/h4H2,(H4,2,3,5)
InChIKey
HAMNKKUPIHEESI-UHFFFAOYSA-N
CAS Number
CAS 79-17-4
PubChem Compound ID
2146
PubChem Substance ID
613675, 4656528, 7885775, 8151457, 10536095, 11110767, 11110768, 11113705, 12014685, 15170355, 16447240, 26717094, 26758204, 29221325, 30387223, 37457865, 38636745, 42873743, 46506441, 47216879, 47736599, 48110553, 49974251, 50104571, 50104572, 50807510, 53788780, 57321170, 87322642, 88824429, 90341334, 90341800, 103513944, 103825641, 104084871, 104299739, 117516744, 124749450, 124879244, 124879245, 124879246, 125334778, 126546077, 127649709, 128032796, 129532113, 129852663, 134339310, 134339703, 134340037
Target and Pathway
Target(s) Nitric oxide synthase, inducible Target Info Inhibitor [537573]
BioCyc Pathway Citrulline-nitric oxide cycle
KEGG Pathway Arginine biosynthesis
Arginine and proline metabolism
Metabolic pathways
Calcium signaling pathway
HIF-1 signaling pathway
Peroxisome
Salmonella infection
Pertussis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Tuberculosis
Pathways in cancer
Small cell lung cancer
NetPath Pathway IL1 Signaling Pathway
IL2 Signaling Pathway
Pathway Interaction Database IL12-mediated signaling events
Alpha9 beta1 integrin signaling events
ATF-2 transcription factor network
IL23-mediated signaling events
Signaling mediated by p38-alpha and p38-beta
HIF-1-alpha transcription factor network
Reactome ROS production in response to bacteria
Nitric oxide stimulates guanylate cyclase
WikiPathways Type II interferon signaling (IFNG)
Spinal Cord Injury
AGE/RAGE pathway
Effects of Nitric Oxide
References
Ref 468198(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5135).
Ref 521693ClinicalTrials.gov (NCT00184990) Effect of Selective iNOS Inhibition During Human Endotoxemia. U.S. National Institutes of Health.
Ref 537573Inhibitory effects of aminoguanidine on thyroid follicular carcinoma development in inflamed capsular regions of rats treated with sulfadimethoxine after N-bis(2-hydroxypropyl)nitrosamine-initiation.Cancer Sci. 2009 Jul 1.

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