Drug General Information
Drug ID	D0T1FC
Former ID	DIB001524
Drug Name	PF-4878691
Synonyms	PF-04878691; PF-4171455
Indication	HCV infection [ICD9: 070.4, 070.5, 070.70; ICD10:B17.1, B18.2]		Phase 1	[522524]
Company	Pfizer Inc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1(c2c(cc(n1)C(F)(F)F)n(c(=O)[nH]2)Cc1ccccc1)N
Target and Pathway
Target(s)	Toll-like receptor 7	Target Info	Agonist	[531417]
KEGG Pathway	Toll-like receptor signaling pathway
	Measles
	Influenza A
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	Toll receptor signaling pathway
Reactome	Trafficking and processing of endosomal TLR
	TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
	MyD88 dependent cascade initiated on endosome
WikiPathways	Toll-like receptor signaling pathway
	Toll-Like Receptors Cascades
	MyD88 dependent cascade initiated on endosome
	Trafficking and processing of endosomal TLR
	Regulation of toll-like receptor signaling pathway
References
Ref 522524	ClinicalTrials.gov (NCT00810758) Multiple Oral Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of PF-04878691. U.S. National Institutes of Health.
Ref 531417	The innate immune response, clinical outcomes, and ex vivo HCV antiviral efficacy of a TLR7 agonist (PF-4878691). Clin Pharmacol Ther. 2011 Jun;89(6):821-9.

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