Drug General Information
Drug ID	D0PL5F
Former ID	DIB007610
Drug Name	OT-4003
Synonyms	IDDB10966
Indication	Asthma [ICD10:J45]		Terminated	[534337]
Company	LEO Pharma A/S
Structure		Download 2D MOL 3D MOL
Canonical SMILES	n1c2c(cc(cc2)Cl)ccc1/C=C/c1cc(NCc2c(O[C@H](C(=O)O)CCCCC<br />)cccc2)ccc1
Target and Pathway
Target(s)	Cysteinyl leukotriene receptor 1	Target Info	Modulator	[534337]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
	IL4 Signaling Pathway
	IL3 Signaling Pathway
Pathway Interaction Database	Endothelins
Reactome	Leukotriene receptors
	G alpha (q) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 534337	Discovery of OT4003, a novel, potent, and orally active cys-LT1 receptor antagonist. Bioorg Med Chem. 1997 Feb;5(2):415-27.
Ref 534337	Discovery of OT4003, a novel, potent, and orally active cys-LT1 receptor antagonist. Bioorg Med Chem. 1997 Feb;5(2):415-27.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.