Drug General Information
Drug ID	D08IRR
Former ID	DIB005642
Drug Name	Org-10490
Indication	Psychotic disorders [ICD9: 290-299; ICD10:F20-F29]		Terminated	[551630]
Company	Organon BioSciences
Structure		Download 2D MOL 3D MOL
Canonical SMILES	O1c2c(CCN(CCc3c1cccc3)C)cccc2.C(=O)(/C=C\C(=O)O)O
CAS Number	CAS 83507-03-3
Target and Pathway
Target(s)	Dopamine D1 receptor	Target Info	Modulator	[556264]
	D(2) dopamine receptor	Target Info	Modulator	[556264]
KEGG Pathway	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Amphetamine addiction
	Morphine addiction
	Alcoholismhsa04015:Rap1 signaling pathway
	Alcoholism
PANTHER Pathway	Dopamine receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Dopamine receptor mediated signaling pathway
	Nicotine pharmacodynamics pathway
PathWhiz Pathway	Dopamine Activation of Neurological Reward System
Reactome	Dopamine receptors
	G alpha (s) signalling eventsR-HSA-390651:Dopamine receptors
	G alpha (i) signalling events
WikiPathways	Hypothetical Network for Drug Addiction
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Genes and (Common) Pathways Underlying Drug Addiction
	GPCR ligand binding
	GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
	GPCR downstream signaling
	Nicotine Activity on Dopaminergic Neurons
References
Ref 551630	ORG 10490: A new antipsychotic drug with 5-HT2 and DA antagonistic properties. ScienceDirect, Volume 6, Issue 2, January 1992, Pages 111.
Ref 556264	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.