Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0SY9B
|
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| Former ID |
DCL001001
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| Drug Name |
SSR149415
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| Synonyms |
Nelivaptan; SSR 149415; SR-149415; SSR-149415; 1-(5-chloro-1-((2,4-dimethoxyphenyl)sulfonyl)-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl)-4-hydroxy-N,N-dimethyl-2-pyrrolidinecarboxamide
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| Drug Type |
Small molecular drug
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| Company |
Sanofi-Aventis
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| Structure |
|
Download2D MOL |
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| Formula |
C30H32ClN3O8S
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| InChI |
InChI=1S/C30H32ClN3O8S/c1-32(2)28(36)24-15-19(35)17-33(24)30(21-8-6-7-9-25(21)41-4)22-14-18(31)10-12-23(22)34(29(30)37)43(38,39)27-13-11-20(40-3)16-26(27)42-5/h6-14,16,19,24,35H,15,17H2,1-5H3/t19-,24+,30+/m1/s1
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| InChIKey |
NJXZWIIMWNEOGJ-WEWKHQNJSA-N
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| CAS Number |
CAS 439687-69-1
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Vasopressin V1b receptor | Target Info | Antagonist | [536580] | |
| References | |||||
| Ref 535432 | Anxiolytic- and antidepressant-like effects of the non-peptide vasopressin V1b receptor antagonist, SSR149415, suggest an innovative approach for the treatment of stress-related disorders. Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6370-5. Epub 2002 Apr 16. | ||||
| Ref 536580 | Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2. | ||||
| Ref 539402 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2202). | ||||
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