Drug Information

Drug General Information
Drug ID
D0Q7FC
Former ID
DIB000131
Drug Name
Lurtotecan
Synonyms
Lurtotecan dihydrochloride; GI 147211C; GG-147211C; GG-211; GI-147211; GI-147211A; GL-147211C; GW-211
Drug Type
Small molecular drug
Indication Ovarian cancer [ICD9: 183; ICD10:C56] Discontinued in Phase 2 [545826]
Company
Glaxo Inc
Structure
Download
2D MOL

3D MOL
Formula
C28H30N4O6
Canonical SMILES
n12c(c3c(c(c4c(n3)cc3c(c4)OCCO3)CN3CCN(CC3)C)C2)cc2c(c1<br />=O)COC(=O)[C@]2(O)CC.Cl.Cl
PubChem Compound ID
60956
Target and Pathway
Target(s) Toposisomerase-1 Target Info Inhibitor [543672]
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway DNA replication
Pathway Interaction Database Caspase Cascade in Apoptosis
WikiPathways Integrated Pancreatic Cancer Pathway
References
Ref 545826Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004939)
Ref 543672(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2636).

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