Drug Information

Drug General Information
Drug ID
D01ESB
Former ID
DPR000162
Drug Name
YM-992
Synonyms
Lubazodone HCl; Lubazodone hydrochloride; Lubazodone hydrochloride [USAN]; YM992; Lubazodone (TN); Lubazodone hydrochloride (USAN); SM-50C; YM-35992; (2S)-2-[(7-fluoro-2,3-dihydro-1H-inden-4-yl)oxymethyl]morpholine hydrochloride; (S)-2-(((7-fluoro-4-indanyl)oxy)methyl)morpholine hydrochloride
Drug Type
Small molecular drug
Indication Depression [ICD9: 311; ICD10:F30-F39] Discontinued in Phase 2 [546447]
Therapeutic Class
Psychiatric
Company
Yamanouchi
Structure
Download
2D MOL

3D MOL
Formula
C14H19ClFNO2
Canonical SMILES
C1CC2=C(C=CC(=C2C1)F)OCC3CNCCO3.Cl
InChI
1S/C14H18FNO2.ClH/c15-13-4-5-14(12-3-1-2-11(12)13)18-9-10-8-16-6-7-17-10;/h4-5,10,16H,1-3,6-9H2;1H/t10-;/m0./s1
InChIKey
HWEMEKZYQCJVEZ-PPHPATTJSA-N
CAS Number
CAS 161178-07-0
PubChem Compound ID
157918
PubChem Substance ID
10253234, 14799964, 46233436, 47206598, 51556380, 57348449, 113438624, 134447725, 135113521, 136359424, 137134511, 196409686, 198968367, 226677099
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Inhibitor [536286]
Sodium-dependent serotonin transporter Target Info Inhibitor [536286]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04726:Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway 5HT2 type receptor mediated signaling pathwayP04373:5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP727:Monoamine Transport
NRF2 pathway
Synaptic Vesicle Pathway
Serotonin Transporter Activity
References
Ref 546447Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008166)
Ref 536286Serotonin reuptake inhibitors: the corner stone in treatment of depression for half a century--a medicinal chemistry survey. Curr Top Med Chem. 2006;6(17):1801-23.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.