TTD | Drug: D04VDY

Drug General Information
Drug ID	D04VDY
Former ID	DNC004436
Drug Name	L-741671
Drug Type	Small molecular drug
Indication	Emesis [ICD9: 787; ICD10:R11]		Terminated	[546715]
Structure		Download 2D MOL 3D MOL
Formula	C23H22F6N4O2
Canonical SMILES	C1CC(C(N(C1)CC2=NC(=O)NN2)C3=CC=CC=C3)OCC4=CC(=CC(=C4)C<br />(F)(F)F)C(F)(F)F
InChI	1S/C23H22F6N4O2/c24-22(25,26)16-9-14(10-17(11-16)23(27,28)29)13-35-18-7-4-8-33(12-19-30-21(34)32-31-19)20(18)15-5-2-1-3-6-15/h1-3,5-6,9-11,18,20H,4,7-8,12-13H2,(H2,30,31,32,34)/t18-,20-/m0/s1
InChIKey	ZUWHBRRBKKTMQO-ICSRJNTNSA-N
PubChem Compound ID	44152684
Target and Pathway
Target(s)	Substance-P receptor	Target Info	Inhibitor	[534156]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Measles
PANTHER Pathway	CCKR signaling map ST
Reactome	G alpha (q) signalling events
WikiPathways	SIDS Susceptibility Pathways
	Gastrin-CREB signalling pathway via PKC and MAPK
	Spinal Cord Injury
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 546715	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009849)
Ref 534156	J Med Chem. 1996 Jul 19;39(15):2907-14.N-heteroaryl-2-phenyl-3-(benzyloxy)piperidines: a novel class of potent orally active human NK1 antagonists.

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Drug Information