Drug General Information
Drug ID	D0I3BB
Former ID	DIB014371
Drug Name	KW-7158
Synonyms	Non-cholinergic tricyclic (irritable bowel syndrome), Kyowa Hakko Kirin
Drug Type	Small molecular drug
Indication	Urinary incontinence [ICD9: 788.3; ICD10:N39.3, N39.4, R32]		Discontinued in Phase 2	[547139]
Company	Kyowa Hakko
Structure		Download 2D MOL 3D MOL
Formula	C16H12F3NO5S2
Canonical SMILES	O=S1(=O)c2cccc(c2C(=O)c2c(C1)ccs2)NC(=O)[C@@](C(F)(F)F)<br />(O)C
CAS Number	CAS 214764-26-8
PubChem Compound ID	9844981
Target and Pathway
Target(s)	Potassium channel	Target Info	Agonist	[526989]
References
Ref 547139	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013319)
Ref 526989	KW-7158 [(2S)-(+)-3,3,3-trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-dihydrothieno[3,2-c][1]benzothiepin-9-yl)propanamide] enhances A-type K+ currents in neurons of the dorsal root ganglion of the adult rat. J Pharmacol Exp Ther. 2004 Jul;310(1):159-68. Epub 2004 Mar 9.

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