Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D01UNT
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| Former ID |
DNC000773
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| Drug Name |
ICI 200,880
|
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| Drug Type |
Small molecular drug
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| Structure |
|
Download2D MOL |
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| Formula |
C30H34ClF3N4O7S
|
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| Canonical SMILES |
CC(C)C(C(=O)C(F)(F)F)NC(=O)C1CCCN1C(=O)C(C(C)C)NC(=O)C2<br />=CC=C(C=C2)C(=O)NS(=O)(=O)C3=CC=C(C=C3)Cl
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| InChI |
1S/C30H34ClF3N4O7S/c1-16(2)23(25(39)30(32,33)34)35-28(42)22-6-5-15-38(22)29(43)24(17(3)4)36-26(40)18-7-9-19(10-8-18)27(41)37-46(44,45)21-13-11-20(31)12-14-21/h7-14,16-17,22-24H,5-6,15H2,1-4H3,(H,35,42)(H,36,40)(H,37,41)/t22?,23?,24-/m1/s1
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| InChIKey |
YGPYJEFIYYPEEE-KXTRFFEISA-N
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| CAS Number |
CAS 105080-50-0
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Leukocyte elastase | Target Info | Inhibitor | [535494], [537900] | |
| Pathway Interaction Database | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling | ||||
| C-MYB transcription factor network | |||||
| References | |||||
| Ref 535494 | Neutrophil elastase inhibitors as treatment for COPD. Expert Opin Investig Drugs. 2002 Jul;11(7):965-80. | ||||
| Ref 537900 | Neutrophil elastase inhibitor ICI 200,880 protects against attenuation of coronary flow reserve and myocardial dysfunction following temporary coronary artery occlusion in the dog. Cardiovasc Res. 1994 Jul;28(7):947-56. | ||||
| Ref 535494 | Neutrophil elastase inhibitors as treatment for COPD. Expert Opin Investig Drugs. 2002 Jul;11(7):965-80. | ||||
| Ref 537900 | Neutrophil elastase inhibitor ICI 200,880 protects against attenuation of coronary flow reserve and myocardial dysfunction following temporary coronary artery occlusion in the dog. Cardiovasc Res. 1994 Jul;28(7):947-56. | ||||
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