Drug Information

Drug General Information
Drug ID
D05ERT
Former ID
DIB004727
Drug Name
GV-196771
Synonyms
GR-196771; GV-196771A
Drug Type
Small molecular drug
Indication Migraine [ICD9: 346; ICD10:G43] Discontinued in Phase 2 [467542], [546551]
Company
Glaxo Wellcome plc
Structure
Download
2D MOL

3D MOL
Formula
C20H13Cl2N2O3-
InChI
InChI=1S/C20H14Cl2N2O3/c21-12-9-15(22)17-14(18(20(26)27)23-16(17)10-12)8-11-6-7-24(19(11)25)13-4-2-1-3-5-13/h1-5,8-10,23H,6-7H2,(H,26,27)/p-1/b11-8+
InChIKey
VDIRQCDDCGAGET-DHZHZOJOSA-M
PubChem Compound ID
21202952
PubChem Substance ID
35050596, 55259281, 178101025
Target and Pathway
Target(s) Glycine receptor Target Info Modulator [525509]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Ligand-gated ion channel transport
WikiPathways Iron uptake and transport
References
Ref 467542(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4208).
Ref 546551Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008901)
Ref 525509First time in human for GV196771: interspecies scaling applied on dose selection. J Clin Pharmacol. 1999 Jun;39(6):560-6.

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