Drug General Information
Drug ID	D02PIN
Former ID	DIB015880
Drug Name	GR-94839
Drug Type	Small molecular drug
Indication	Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89]		Terminated	[545572]
Company	Glaxo Group Research Ltd
Structure		Download 2D MOL 3D MOL
Formula	C19H25Cl2N3O3
Canonical SMILES	N1(C(CN(C(=O)C)CC1)CN1CC(CC1)O)C(=O)Cc1cc(c(cc1)Cl)Cl
CAS Number	CAS 133407-20-2
PubChem Compound ID	131626
Target and Pathway
Target(s)	Kappa-type opioid receptor	Target Info	Modulator	[526749]
KEGG Pathway	Neuroactive ligand-receptor interaction
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Opioid prodynorphin pathway
Reactome	Peptide ligand-binding receptors
	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545572	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003733)
Ref 526749	GR94839, a kappa-opioid agonist with limited access to the central nervous system, has antinociceptive activity. Br J Pharmacol. 1992 Aug;106(4):783-9.

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