Drug Information

Drug General Information
Drug ID
D05REL
Former ID
DIB006211
Drug Name
GR-82334
Indication Emesis [ICD9: 787; ICD10:R11] Terminated [546010]
Company
Glaxo Group Research Ltd
Structure
Download
2D MOL

3D MOL
Formula
C69H91N15O16
Canonical SMILES
N1(C(=O)[C@@]2(N(C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](<br />NC(=O)[C@@H](NC(=O)[C@H]3N(C(=O)[C@@H](NC(=O)[C@@H](NC(<br />=O)[C@H]4NC(=O)CC4)C)CC(=O)O)CCC3)CC(=O)N)CCCCN)Cc3cccc<br />c3)Cc3ccc(cc3)O)CCC2)CC1)[C@H](C(=O)N[C@H](C(=O)N)Cc1c[<br />nH]c2c1cccc2)CC(C)C
CAS Number
CAS 129623-01-4
PubChem Compound ID
16130972
Target and Pathway
Target(s) Substance-P receptor Target Info Antagonist [526764]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Measles
PANTHER Pathway CCKR signaling map ST
Reactome G alpha (q) signalling events
WikiPathways SIDS Susceptibility Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 546010Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005872)
Ref 526764Effect of the NK-1 receptor antagonist GR 82,334 on reflexly-induced bladder contractions. Life Sci. 1992;51(26):PL277-80.

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