Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0B2CQ
|
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| Former ID |
DIB001201
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| Drug Name |
GR-131663
|
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| Synonyms |
AH-002; AH-017; GR-131665
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| Indication | Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] | Terminated | [1] | ||
| Company |
Glaxo Group Research Ltd
|
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
c12c(CCC(NC(=O)CCl)C1)cccc2OC
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| CAS Number |
CAS 134865-72-8
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| Target and Pathway | |||||
| Target(s) | Melatonin receptor | Target Info | Modulator | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Circadian entrainment | |||||
| Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Small Ligand GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003455) | ||||
| REF 2 | Novel non-indolic melatonin receptor agonists differentially entrain endogenous melatonin rhythm and increase its amplitude. Eur J Pharmacol. 1999 Oct 15;382(3):157-66. | ||||
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