Drug General Information
Drug ID
D0Z1PA
Former ID
DIB009945
Drug Name
GG-818
Synonyms
GI-231818; GW-1818
Indication Prostate disease [ICD10:N42.9] Investigative [534666]
Company
Glaxo Wellcome plc
Structure
Download
2D MOL

3D MOL

Canonical SMILES
S(=O)(=O)(c1c(ccc(c1)CCN1CCC(c2nc(c(o2)c2ccc(cc2)F)COCC<br />(F)(F)F)CC1)OC)N
CAS Number
CAS 179535-60-5
Target and Pathway
Target(s) Alpha-1A adrenergic receptor Target Info Antagonist [534666]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
AMPK signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretion
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
AMPK Signaling
References
Ref 534666In situ salt screening--a useful technique for discovery support and preformulation studies. Pharm Dev Technol. 1998 May;3(2):215-23.
Ref 534666In situ salt screening--a useful technique for discovery support and preformulation studies. Pharm Dev Technol. 1998 May;3(2):215-23.

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