Drug General Information
Drug ID	D08CKJ
Former ID	DIB012702
Drug Name	Fonsartan
Synonyms	HR-720; Hoe-720
Indication	Hypertension [ICD9: 401; ICD10:I10-I16]		Discontinued in Phase 2	[545886]
Company	Hoechst Marion Roussel Inc; Hoechst AG
Structure		Download 2D MOL 3D MOL
Canonical SMILES	S(=O)(=O)([N-]C(=O)NCCC)c1c(c2ccc(Cn3c(c(nc3CCCC)SC)C(=<br />O)[O-])cc2)cccc1.[K+].[K+]
CAS Number	CAS 153235-15-5
Target and Pathway
Target(s)	Type-2 angiotensin II receptor	Target Info	Modulator	[534815]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Adrenergic signaling in cardiomyocytes
	Renin-angiotensin system
Reactome	Peptide ligand-binding receptors
	G alpha (i) signalling events
WikiPathways	ACE Inhibitor Pathway
	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545886	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005209)
Ref 534815	Role of the angiotensin II AT2-subtype receptors in the blood pressure-lowering effect of losartan in salt-restricted rats. J Hypertens. 1998 Dec;16(12 Pt 2):2039-43.

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