Drug Information

Drug General Information
Drug ID
D0RL4M
Former ID
DNC014747
Drug Name
Pranazepide
Drug Type
Small molecular drug
Indication Pancreatic disease [ICD10:K85-K86] Discontinued in Phase 2 [543265], [545379]
Structure
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2D MOL

3D MOL
Formula
C26H19FN4O2
InChI
InChI=1S/C26H19FN4O2/c27-19-10-3-2-8-17(19)22-18-9-5-7-15-12-13-31(23(15)18)26(33)24(29-22)30-25(32)21-14-16-6-1-4-11-20(16)28-21/h1-11,14,24,28H,12-13H2,(H,30,32)/t24-/m1/s1
InChIKey
WKJDXKWFGJWGAS-XMMPIXPASA-N
PubChem Compound ID
132916
PubChem Substance ID
7848920, 10243231, 14856963, 14905802, 29310942, 47434843, 48329057, 50803432, 57344307, 103231644, 104131952, 104378531, 124894212, 129594237, 134351952, 135088066, 135650262, 137263890, 144206813, 179149968, 184547845, 198935329, 228249046
Target and Pathway
Target(s) Cholecystokinin receptor type A Target Info Inhibitor [551329]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Insulin secretion
Pancreatic secretion
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 543265(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 874).
Ref 545379Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003071)
Ref 551329Dual CCK-A and -B receptor antagonists (I) C9-methyl-1,4-benzodiazepines, Bioorg. Med. Chem. Lett. 7(2):169-174 (1997).

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