Drug General Information
Drug ID	D07XDQ
Former ID	DIB008200
Drug Name	Figopitant
Synonyms	BIIF-1149; BIIF-1149CL; NK1 antagonists, Boehringer Ingelheim
Drug Type	Small molecular drug
Indication	Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1]		Phase 1	[524845]
Company	Boehringer Ingelheim Corp
Structure		Download 2D MOL 3D MOL
Formula	C27H31F6N3O
Canonical SMILES	[C@H](N1CCN(CC1)CC1CC1)(c1ccccc1)C(=O)N(CCc1cc(cc(c1)C(<br />F)(F)F)C(F)(F)F)C
PubChem Compound ID	9914857
Target and Pathway
Target(s)	Substance-P receptor	Target Info	Antagonist	[531741]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Measles
PANTHER Pathway	CCKR signaling map ST
Reactome	G alpha (q) signalling events
WikiPathways	SIDS Susceptibility Pathways
	Gastrin-CREB signalling pathway via PKC and MAPK
	Spinal Cord Injury
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 524845	ClinicalTrials.gov (NCT02199899) Safety, Tolerability and Pharmacodynamics of BIIF 1149 BS in Healthy Young Male Volunteers. U.S. National Institutes of Health.
Ref 531741	Investigation of figopitant and its metabolites in rat tissue by combining whole-body autoradiography with liquid extraction surface analysis mass spectrometry. Drug Metab Dispos. 2012 Mar;40(3):419-25.

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