Drug Information

Drug General Information
Drug ID
D08SZO
Former ID
DIB001485
Drug Name
F-12458
Synonyms
CAAX tetrapeptide analogs, Pierre Fabre; F-12458; Farnesyl transferase inhibitors, Pierre Fabre; Ras inhibitor, Pierre Fabre
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Investigative [527662]
Company
Pierre Fabre SA
Structure
Download
2D MOL

3D MOL
Canonical SMILES
c1(C(=O)N2CCN(c3ccc(N(C(=O)c4cc(Cl)ccc4)Cc4n(cnc4)Cc4cc<br />c(C#N)cc4)cc3)CC2)sc(cc1)Cl
Target and Pathway
Target(s) Protein farnesyltransferase beta subunit Target Info Inhibitor [527662]
KEGG Pathway Terpenoid backbone biosynthesis
Biosynthesis of antibiotics
NetPath Pathway TSH Signaling Pathway
Reactome Inactivation, recovery and regulation of the phototransduction cascade
WikiPathways Visual phototransduction
References
Ref 527662Recent progress in protein farnesyltransferase inhibition. IDrugs. 2000 Nov;3(11):1336-45.
Ref 527662Recent progress in protein farnesyltransferase inhibition. IDrugs. 2000 Nov;3(11):1336-45.

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