Drug General Information
Drug ID	D0Y0ZQ
Former ID	DIB012444
Drug Name	Ecabapide
Synonyms	Ecabamide; Muralis; DQ-2511
Drug Type	Small molecular drug
Indication	Peptic ulcer [ICD9: 531-534; ICD10:K25-K27]		Discontinued in Preregistration	[544686]
Company	Daiichi Seiyaku Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C20H25N3O4
Canonical SMILES	C(=O)(c1cc(NCC(=O)NCCc2cc(c(cc2)OC)OC)ccc1)NC
CAS Number	CAS 104775-36-2
PubChem Compound ID	65885
Target and Pathway
Target(s)	Alpha-2C adrenergic receptor	Target Info	Modulator	[534260]
KEGG Pathway	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
PANTHER Pathway	Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome	Adrenoceptors
	Adrenaline signalling through Alpha-2 adrenergic receptor
	Adrenaline,noradrenaline inhibits insulin secretion
	G alpha (i) signalling events
	G alpha (z) signalling events
	Surfactant metabolism
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Platelet Aggregation (Plug Formation)
	Integration of energy metabolism
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 544686	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000582)
Ref 534260	Identification of major biliary and urinary metabolites of ecabapide in rats. Xenobiotica. 1996 Sep;26(9):983-94.

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