Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D00SPK
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| Former ID |
DIB004276
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| Drug Name |
E-4021
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| Drug Type |
Small molecular drug
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| Indication | Cardiovascular disorder [ICD10:I00-I99] | Discontinued in Phase 2 | [1] | ||
| Company |
Eisai Co Ltd
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| Structure |
|
Download2D MOL |
|||
| Formula |
C22H20ClN4NaO4
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| Canonical SMILES |
c12c(nc(nc1ccc(c2)Cl)N1CCC(CC1)C(=O)[O-])NCc1cc2c(cc1)O<br />CO2.[Na+]
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| CAS Number |
CAS 150452-18-9
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | CGMP-specific 3',5'-cyclic phosphodiesterase | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Purine metabolism | ||||
| cGMP-PKG signaling pathway | |||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
| Reactome | cGMP effects | ||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004019) | ||||
| REF 2 | Potency and mechanism of action of E4021, a type 5 phosphodiesterase isozyme-selective inhibitor, on the photoreceptor phosphodiesterase depend on the state of activation of the enzyme. Mol Pharmacol. 1999 Mar;55(3):508-14. | ||||
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