Drug General Information
Drug ID	D0F4IG
Former ID	DIB003717
Drug Name	DS-4574
Drug Type	Small molecular drug
Indication	Asthma [ICD10:J45]		Discontinued in Phase 2	[544688]
Company	Daiichi Seiyaku Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C13H16N6OS
Canonical SMILES	n12c(nc3c(c1=O)[nH]nn3)sc(n2)CCC1CCCCC1
CAS Number	CAS 118314-35-5
PubChem Compound ID	159491
Target and Pathway
Target(s)	Cysteinyl leukotriene receptor 1	Target Info	Modulator	[533854]
	Leukotriene CysLT2 receptor	Target Info	Modulator	[533854]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
	Neuroactive ligand-receptor interaction
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
	IL4 Signaling Pathway
	IL3 Signaling PathwayNetPath_16:IL4 Signaling Pathway
	IL3 Signaling Pathway
Pathway Interaction Database	Endothelinsendothelinpathway:Endothelins
Reactome	Leukotriene receptors
	G alpha (q) signalling eventsR-HSA-391906:Leukotriene receptors
	G alpha (q) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
	GPCR downstream signaling
References
Ref 544688	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000587)
Ref 533854	Inhibitory effect of DS-4574, a mast cell stabilizer with peptidoleukotriene receptor antagonism, on gastric acid secretion in rats. Eur J Pharmacol. 1994 Apr 1;255(1-3):229-34.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.