Drug General Information
Drug ID	D0X5BD
Former ID	DIB000558
Drug Name	AVE-5997
Synonyms	AVE-1734; AVE-5997; Dopamine D3 antagonists, Aventis; HMR-2554
Indication	Psychotic disorders [ICD9: 290-299; ICD10:F20-F29]		Discontinued in Phase 1	[547685]
Company	Aventis Pharma AG
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1(c2c(sc1)cc(C(F)(F)F)cc2)N1CCN(CC1)CCCCNC(=O)Nc1ccc(c<br />c1)C
Target and Pathway
Target(s)	D(3) dopamine receptor	Target Info	Antagonist	[527957]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Dopaminergic synapse
Reactome	Dopamine receptors
	G alpha (i) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
	Nicotine Activity on Dopaminergic Neurons
	GPCRs, Other
References
Ref 547685	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018413)
Ref 527957	Effect of dopamine D3 antagonists on PPI in DBA/2J mice or PPI deficit induced by neonatal ventral hippocampal lesions in rats. Neuropsychopharmacology. 2006 Jul;31(7):1382-92. Epub 2005 Dec 14.

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