Drug General Information
Drug ID	D0L7SY
Former ID	DIB000905
Drug Name	Delequamine hydrochloride
Synonyms	Delquamine; RS-15385-197; RS-15385-FP; RS-15385-FPh
Drug Type	Small molecular drug
Indication	Male sexual disorders [ICD10:F52]		Discontinued in Phase 3	[546534]
Company	Roche Bioscience
Structure		Download 2D MOL 3D MOL
Formula	C18H27ClN2O3S
Canonical SMILES	S(=O)(=O)(N1[C@H]2C[C@@H]3N(C[C@H]2CCC1)CCc1c3ccc(c1)OC<br />)C.Cl
CAS Number	CAS 119942-75-5
PubChem Compound ID	168898
Target and Pathway
Target(s)	Alpha-2C adrenergic receptor	Target Info	Modulator	[534174]
KEGG Pathway	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
PANTHER Pathway	Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome	Adrenoceptors
	Adrenaline signalling through Alpha-2 adrenergic receptor
	Adrenaline,noradrenaline inhibits insulin secretion
	G alpha (i) signalling events
	G alpha (z) signalling events
	Surfactant metabolism
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Platelet Aggregation (Plug Formation)
	Integration of energy metabolism
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 546534	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008832)
Ref 534174	Modulation of sexual behaviour in the rat by a potent and selective alpha 2-adrenoceptor antagonist, delequamine (RS-15385-197). Br J Pharmacol. 1996 May;118(1):63-72.

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