Drug General Information
Drug ID	D0KR3X
Former ID	DIB004946
Drug Name	CGS-30440
Indication	Hypertension [ICD9: 401; ICD10:I10-I16]		Terminated	[534574]
Company	Ciba-Geigy Corp
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C(=O)(NC1(C(=O)N[C@H](C(=O)OCC)Cc2ccc(cc2)OC)CCCC1)[C@@<br />H](SC(=O)C)C(C)C
CAS Number	CAS 169319-62-4
Target and Pathway
Target(s)	Neutral endopeptidase	Target Info	Modulator	[534574]
	Angiotensin-converting enzyme	Target Info	Modulator	[534574]
KEGG Pathway	Renin-angiotensin system
	Hematopoietic cell lineage
	Protein digestion and absorption
	Alzheimer's diseasehsa04614:Renin-angiotensin system
	Chagas disease (American trypanosomiasis)
	Hypertrophic cardiomyopathy (HCM)
NetPath Pathway	EGFR1 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway	Angiotensin Metabolism
Reactome	Metabolism of Angiotensinogen to AngiotensinsR-HSA-2022377:Metabolism of Angiotensinogen to Angiotensins
WikiPathways	Metabolism of Angiotensinogen to Angiotensins
	Primary Focal Segmental Glomerulosclerosis FSGS
	Alzheimers DiseaseWP554:ACE Inhibitor Pathway
References
Ref 534574	Antihypertensive and natriuretic effects of CGS 30440, a dual inhibitor of angiotensin-converting enzyme and neutral endopeptidase 24.11. J Pharmacol Exp Ther. 1998 Mar;284(3):974-82.
Ref 534574	Antihypertensive and natriuretic effects of CGS 30440, a dual inhibitor of angiotensin-converting enzyme and neutral endopeptidase 24.11. J Pharmacol Exp Ther. 1998 Mar;284(3):974-82.

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