Drug General Information
Drug ID	D0J7AI
Former ID	DIB000154
Drug Name	BN-80245
Synonyms	DU-1441; DU-1442
Drug Type	Small molecular drug
Indication	Cancer [ICD9: 140-229; ICD10:C00-C96]		Terminated	[546946]
Company	Institut Henri Beaufour
Structure		Download 2D MOL 3D MOL
Formula	C21H18N2O4
Canonical SMILES	n12c(c3c(C2)cc2c(n3)cccc2)cc2c(c1=O)COC(=O)CC2(O)CC
PubChem Compound ID	9863779
Target and Pathway
Target(s)	Toposisomerase-1	Target Info	Inhibitor	[551651]
NetPath Pathway	IL2 Signaling Pathway
PANTHER Pathway	DNA replication
Pathway Interaction Database	Caspase Cascade in Apoptosis
WikiPathways	Integrated Pancreatic Cancer Pathway
References
Ref 546946	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011416)
Ref 551651	BN 80245: An E-ring modified camptothecin with potent antiproliferative and topoisomerase I inhibitory activities. Bioorganic & Medicinal Chemistry Letters Volume 7, Issue 17, 9 September 1997, Pages2235-2238.

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