Drug General Information
Drug ID	D0X8MI
Former ID	DIB010051
Drug Name	Berupipam
Synonyms	NNC-22-0010
Drug Type	Small molecular drug
Indication	Psychotic disorders [ICD9: 290-299; ICD10:F20-F29]		Discontinued in Phase 1	[545634]
Company	Novo Nordisk A/S
Structure		Download 2D MOL 3D MOL
Formula	C19H19BrClNO2
Canonical SMILES	c1([C@@H]2c3c(cc(c(c3)O)Cl)CCN(C2)C)c2c(cc(c1)Br)CCO2
CAS Number	CAS 150490-85-0
PubChem Compound ID	66002
Target and Pathway
Target(s)	Dopamine D1 receptor	Target Info	Antagonist	[533594]
KEGG Pathway	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Amphetamine addiction
	Morphine addiction
	Alcoholism
PANTHER Pathway	Dopamine receptor mediated signaling pathway
PathWhiz Pathway	Dopamine Activation of Neurological Reward System
Reactome	Dopamine receptors
	G alpha (s) signalling events
WikiPathways	Hypothetical Network for Drug Addiction
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Genes and (Common) Pathways Underlying Drug Addiction
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545634	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004006)
Ref 533594	Characterization of benzazepine UDP-glucuronosyl-transferases in laboratory animals and man. Xenobiotica. 1995 Jun;25(6):611-22.

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