Drug Information

Drug General Information
Drug ID
D0Z9HW
Former ID
DCL000474
Drug Name
AZD6280
Drug Type
Small molecular drug
Indication Anxiety disorder; Schizophrenia [ICD9: 295, 300; ICD10:F20, F40-F42] Discontinued in Phase 1 [548677]
Company
AstraZeneca
Structure
Download
2D MOL

3D MOL
Formula
C34H27FN2O10
Canonical SMILES
COC1=CC(=CC=C2C=CC3=C(N2)C(=C(C=C3)C(=O)O)O)C=C(C1=O)O.<br />C1=CN(C(=C1)C(=O)CC(=O)C(=O)O)CC2=CC=C(C=C2)F
InChI
1S/C19H15NO6.C15H12FNO4/c1-26-15-9-10(8-14(21)18(15)23)2-5-12-6-3-11-4-7-13(19(24)25)17(22)16(11)20-12;16-11-5-3-10(4-6-11)9-17-7-1-2-12(17)13(18)8-14(19)15(20)21/h2-9,20-22H,1H3,(H,24,25);1-7H,8-9H2,(H,20,21)/b10-2+,12-5+;
InChIKey
SSYJRKJXHKARRK-MSXHNFCKSA-N
PubChem Compound ID
6320564
PubChem Substance ID
7842109, 42971012, 50842638, 114478465, 134339078
Target and Pathway
Target(s) Gamma-aminobutyric-acid receptor alpha-3 subunit Target Info Modulator
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 548677Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027607)

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