Drug Information
Drug General Information | |||||
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Drug ID |
D08ODH
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Former ID |
DIB002306
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Drug Name |
Atiratecan
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Synonyms |
CH-0793011; CH-0793076; CH-4556300; TP-300
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Drug Type |
Small molecular drug
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Indication | Colorectal cancer [ICD9: 153, 154; ICD10:C18-C21] | Discontinued in Phase 2 | [548306] | ||
Company |
Chugai Pharmaceutical Co Ltd
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Structure |
Download2D MOL |
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Formula |
C31H34N6O6
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Canonical SMILES |
c1ccc2nc3c(c4c2c1ncn4CCCCC)Cn1c3cc2c(c1=O)COC(=O)[C@@]2<br />(CC)OC(=O)CN(C(=O)CN)C
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Toposisomerase-1 | Target Info | Inhibitor | [531647] | |
NetPath Pathway | IL2 Signaling Pathway | ||||
PANTHER Pathway | DNA replication | ||||
Pathway Interaction Database | Caspase Cascade in Apoptosis | ||||
WikiPathways | Integrated Pancreatic Cancer Pathway | ||||
References | |||||
Ref 531647 | Method development and validation of the simultaneous determination of a novel topoisomerase 1 inhibitor, the prodrug, and the active metabolite in human plasma using column-switching LC-MS/MS, and its application in a clinical trial. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Nov 15;879(30):3415-22. |
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