Drug Information

Drug General Information
Drug ID
D0KE4Z
Former ID
DIB016602
Drug Name
ARL-67085
Synonyms
AR-C 67085XX; AR-C67085MX; AR-C67775XX; FPL-67085; FPL-67085MX; SPL-67085
Drug Type
Small molecular drug
Indication Thrombosis [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82] Phase 1 [525640], [539107]
Company
Fisons plc
Structure
Download
2D MOL

3D MOL
Formula
C14H22Cl2N5O12P3S
InChI
InChI=1S/C14H22Cl2N5O12P3S/c1-2-3-37-13-19-10(17)7-11(20-13)21(5-18-7)12-9(23)8(22)6(32-12)4-31-36(29,30)33-35(27,28)14(15,16)34(24,25)26/h5-6,8-9,12,22-23H,2-4H2,1H3,(H,27,28)(H,29,30)(H2,17,19,20)(H2,24,25,26)/t6-,8-,9-,12-/m1/s1
InChIKey
ZLIAJZQKKBOFJR-WOUKDFQISA-N
PubChem Compound ID
5310954
PubChem Substance ID
14790114, 23941547, 39340695, 78815664, 103366622, 104011560, 114154917, 135649953, 198992438
Target and Pathway
Target(s) P2Y purinoceptor 12 Target Info Agonist [525640]
KEGG Pathway Platelet activation
Reactome P2Y receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 525640Pharmacological characterization of the human P2Y11 receptor. Br J Pharmacol. 1999 Nov;128(6):1199-206.
Ref 539107(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1756).
Ref 525640Pharmacological characterization of the human P2Y11 receptor. Br J Pharmacol. 1999 Nov;128(6):1199-206.

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