Drug General Information
Drug ID	D05XTO
Former ID	DIB013864
Drug Name	ABT-100
Synonyms	A-367074; A-409100; A-367074.1
Drug Type	Small molecular drug
Indication	Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48]		Terminated	[547784]
Company	Abbott Laboratories
Structure		Download 2D MOL 3D MOL
Formula	C27H19F3N4O3
Canonical SMILES	c1([C@](COc2c(c3ccc(OC(F)(F)F)cc3)cc(C#N)cc2)(c2ccc(C#N<br />)cc2)O)n(cnc1)C.Cl
PubChem Compound ID	6451154
Target and Pathway
Target(s)	Protein farnesyltransferase beta subunit	Target Info	Inhibitor	[527723]
KEGG Pathway	Terpenoid backbone biosynthesis
	Biosynthesis of antibiotics
NetPath Pathway	TSH Signaling Pathway
Reactome	Inactivation, recovery and regulation of the phototransduction cascade
WikiPathways	Visual phototransduction
References
Ref 547784	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019239)
Ref 527723	Potent farnesyltransferase inhibitor ABT-100 abrogates acute allograft rejection. J Heart Lung Transplant. 2005 Sep;24(9):1403-9.

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