Drug Information

Drug General Information
Drug ID
D03XUQ
Former ID
DIB007317
Drug Name
ABS-212
Synonyms
Neurotensin derivative (pain), Argolyn
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Terminated [540761], [548547]
Company
Argolyn Bioscience Inc
Structure
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2D MOL

3D MOL
Canonical SMILES
[C@@H]1(C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)[O-])C<br />C(C)C)C(C)(C)C)Cc2ccc(cc2)O)CCCN1C(=O)[C@@H](NC(=O)[C@H<br />](CCC[N+](C)(C)C)C)CCCNC(=N)N
Target and Pathway
Target(s) Neurotensin receptor type 1 Target Info Agonist [530926]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 540761(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5307).
Ref 548547Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026502)
Ref 530926Identification and functional characterization of a stable, centrally active derivative of the neurotensin (8-13) fragment as a potential first-in-class analgesic. J Med Chem. 2010 Jun 24;53(12):4623-32.

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