Drug Information
Drug General Information | |||||
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Drug ID |
D0O2XQ
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Former ID |
DCL000040
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Drug Name |
AMD-070
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Synonyms |
AMD 070; AMD070; AMD11070; S14-0353; N-(1H-benzoimidazol-2-ylmethyl)-N-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine; N'-(1H-Benzo[d]imidazol-2-ylmethyl)-N'-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine Trihydrobromide Dihydrate
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Drug Type |
Small molecular drug
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Company |
Genzyme
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Structure |
Download2D MOL |
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Formula |
C21H27N5
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InChI |
InChI=1S/C21H27N5/c22-12-3-4-14-26(15-20-24-17-9-1-2-10-18(17)25-20)19-11-5-7-16-8-6-13-23-21(16)19/h1-2,6,8-10,13,19H,3-5,7,11-12,14-15,22H2,(H,24,25)/t19-/m0/s1
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InChIKey |
WVLHHLRVNDMIAR-IBGZPJMESA-N
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PubChem Compound ID | |||||
PubChem Substance ID |
16341997, 23432776, 42336114, 78221842, 103048053, 103640995, 104149666, 134338746, 135267514, 141439559, 152258793, 160647644, 160832429, 163095501, 163312006, 163397643, 163686447, 163843959, 164044123, 186014814, 189659314, 198950476, 204429418, 223595086, 228616596, 241105059, 245507406, 249855948, 250212843, 251962956, 252067924, 252166781, 252211781, 252438061, 252506245
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Target and Pathway | |||||
Target(s) | C-X-C chemokine receptor 4 | Target Info | Antagonist | [536630], [536663] | |
References | |||||
Ref 521607 | ClinicalTrials.gov (NCT00089466) Safety and Activity of the Oral HIV Entry Inhibitor AMD11070 in HIV Infected Patients. U.S. National Institutes of Health. | ||||
Ref 543204 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8580). | ||||
Ref 536630 | Effect of low-dose ritonavir on the pharmacokinetics of the CXCR4 antagonist AMD070 in healthy volunteers. Antimicrob Agents Chemother. 2008 May;52(5):1630-4. Epub 2008 Feb 19. | ||||
Ref 536663 | Pharmacokinetic effect of AMD070, an Oral CXCR4 antagonist, on CYP3A4 and CYP2D6 substrates midazolam and dextromethorphan in healthy volunteers. J Acquir Immune Defic Syndr. 2008 Apr 15;47(5):559-65. |
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