Drug Information

Drug General Information
Drug ID
D0IP6X
Former ID
DCL000191
Drug Name
Osanetant
Synonyms
Osanetant [INN]; SB-236984; SR-14280; SR-142801; SR-142806; N-[1-[3-[(3R)-1-benzoyl-3-(3,4-dichlorophenyl)piperidin-3-yl]propyl]-4-phenylpiperidin-4-yl]-N-methylacetamide; N-(1-{3-[(3r)-1-benzoyl-3-(3,4-dichlorophenyl)piperidin-3-yl]propyl}-4-phenylpiperidin-4-yl)-n-methylacetamide; N-(1-(3-((3R)-1-benzoyl-3-(3,4-dichlorophenyl)-3-piperidinyl)propyl)-4-phenyl-4-piperidinyl)-N-methylacetamide; N-(1-(3-((R)-1-Benzoyl-3-(3,4-dichlorophenyl)-3-piperidyl)propyl)-4-phenyl-4-piperidyl)-N-methylacetamide
Drug Type
Small molecular drug
Indication Schizophrenia; Schizoaffective disorders [ICD9: 295, 295.70; ICD10:F20, F25] Discontinued in Phase 2b [536463], [539337]
Depression [ICD9: 311; ICD10:F30-F39] Terminated [536463], [539337]
Company
Sanofi-aventis
Structure
Download
2D MOL

3D MOL
Formula
C35H41Cl2N3O2
InChI
InChI=1S/C35H41Cl2N3O2/c1-27(41)38(2)35(29-13-7-4-8-14-29)19-23-39(24-20-35)21-9-17-34(30-15-16-31(36)32(37)25-30)18-10-22-40(26-34)33(42)28-11-5-3-6-12-28/h3-8,11-16,25H,9-10,17-24,26H2,1-2H3/t34-/m0/s1
InChIKey
DZOJBGLFWINFBF-UMSFTDKQSA-N
CAS Number
CAS 160492-56-8
PubChem Compound ID
219077
PubChem Substance ID
9374273, 14765045, 14789447, 30422444, 47583780, 48329110, 50068883, 50070629, 50182021, 57304375, 57399839, 85286118, 90342450, 103399782, 103831276, 104132813, 113468548, 117463754, 126671662, 127809701, 134338860, 135650780, 137265093, 137275954, 141237279, 144116320, 152035367, 164780141, 175426879, 178100471, 198978083, 223660710, 223704871, 226491182, 252160228
Target and Pathway
Target(s) Nigral tachykinin NK(3) receptor Target Info Antagonist [536865], [536894], [537495]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Reactome G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 536463The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31.
Ref 539337(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2110).
Ref 536865Augmentation of antipsychotic-induced neurochemical changes by the NK3 receptor antagonist talnetant (SB-223412). Neuropharmacology. 2009 Feb;56(2):342-9. Epub 2008 Sep 18.
Ref 536894The tachykinin NK3 receptor agonist senktide induces locomotor activity in male Mongolian gerbils. Eur J Pharmacol. 2008 Dec 14;600(1-3):87-92. Epub 2008 Oct 10.
Ref 537495Pharmacological characterization of senktide-induced tail whips. Neuropharmacology. 2009 Jun 21.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.