Drug Information

Drug General Information
Drug ID
D05EAM
Former ID
DAP000764
Drug Name
Pentamidine
Synonyms
Lomidine; Nebupent; PENTAM; PNT; Pentacarinat; Pentamide; Pentamidin; Pentamidina; Pentamidinum; Pneumopent; PENTAMIDINE ISETHIONATE; Pentamidina [DCIT]; Pentamidine isetionate; Pentamidine mesylate; MB 800; Pentam 300; Lomidine (TN); MB-800; Nebupent (as isethionate); Pentacarinat (as isethionate); Pentam 300 (as isethionate); Pentamidine (INN); Pentamidinum [INN-Latin]; RP-2512; Nebupent (*Isethionate); Pentacarinat (*Isethionate); Pentam 300 (*Isethionate); Pentamidine Isethionate 2-Hydroxy-Ethanesulfonic Acid;Pentamidine [INN:BAN:DCF]; RP 2512 (*Isethionate); P,p'-(Pentamethylenedioxy)bis[benzamidine]; P,p'-(Pentamethylenedioxy)dibenzamidine; P,p'-(Pentamethylene-dioxy)bis-benzamidine; Benzenecarboximidamide, 4,4'-(1,5-pentanediylbis(oxy))bis-(9CI); 1,3-BIS(4-AMIDINOPHENOXY)PENTANE; 4, 4'-Diamidinodiphenoxypentane; 4,4'-(1,5-Pentanediylbis(oxy))bis-benzenecarboximidamide; 4,4'-(Pentamethylenedioxy)dibenzamide; 4,4'-(Pentamethylenedioxy)dibenzamidine; 4,4'-Diamidino-.alpha.,.omega.-diphenoxypentane; 4,4'-Diamidinodiphenoxypentane; 4,4'-[pentane-1,5-diylbis(oxy)]dibenzenecarboximidamide; 4-[5-(4-Carbamimidoylphenoxy)pentoxy]benzenecarboximidamide
Drug Type
Small molecular drug
Indication Fungal infections [ICD9: 110-118; ICD10:B35-B49] Approved [536135]
Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26] Withdrawn from market [551871]
Therapeutic Class
Antifungal Agents
Structure
Download
2D MOL

3D MOL
Formula
C19H24N4O2
Canonical SMILES
C1=CC(=CC=C1C(=N)N)OCCCCCOC2=CC=C(C=C2)C(=N)N
InChI
1S/C19H24N4O2/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23)
InChIKey
XDRYMKDFEDOLFX-UHFFFAOYSA-N
CAS Number
CAS 100-33-4
PubChem Compound ID
4735
PubChem Substance ID
9624, 75273, 596087, 7687717, 7889974, 7980274, 8152906, 11371352, 11374018, 11446573, 11467701, 11484026, 11486282, 11487971, 11490092, 11492195, 14802371, 24262996, 26697116, 26704279, 29223821, 46508562, 47515246, 47810678, 47810679, 47959662, 48110386, 48184930, 48416390, 49698900, 49829609, 49877520, 50096576, 50123735, 50123736, 53787921, 57322420, 78291630, 81061089, 85256751, 85261596, 88835490, 90944750, 92308870, 92711694, 96025020, 103167313, 103927078, 104307277, 117524407
ChEBI ID
ChEBI:45081
SuperDrug ATC ID
P01CX01
SuperDrug CAS ID
cas=000140647
Target and Pathway
Target(s) Tryptase Target Info Inhibitor [534849], [537936]
Reactome Activation of Matrix Metalloproteinases
References
Ref 536135Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005 Sep;4(9):727-40.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 534849Inhibitors of tryptase for the treatment of mast cell-mediated diseases. Curr Pharm Des. 1998 Oct;4(5):381-96.
Ref 537936Bis(5-amidino-2-benzimidazolyl)methane and related amidines are potent, reversible inhibitors of mast cell tryptases. J Pharmacol Exp Ther. 1993 Feb;264(2):676-82.

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