Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09UZO
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| Former ID |
DAP000147
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| Drug Name |
Mercaptopurine
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| Synonyms |
Ismipur; Leukerin; Leupurin; Mercaleukim; Mercaleukin; Mercaptopurin; Mercaptopurina; Mercaptopurinum; Mercapurin; Merkaptopuryna; Mern; Purimethol; Purinethiol; Purinethol; Thiopurine; Leupu rin; Mercaptopurin [German]; Mercaptopurina Wellcome; Mercaptopurine anhydrous; Merkaptopuryna [Polish]; Puri Nethol; BW 57 323H; Glaxo Wellcome Brand of 6 Mercaptopurine; GlaxoSmithKline Brand of 6 Mercaptopurine; M0063; NCIMech_000025; PM6; Wellcome Brand of 6 Mercaptopurine; Glaxo Wellcome Brand of 6-Mercaptopurine; GlaxoSmithKline Brand of 6-Mercaptopurine; Mercaptopurina [INN-Spanish]; Mercaptopurine (INN); Mercaptopurine (VAN); Mercaptopurine (anhydrous); Mercaptopurinum [INN-Latin]; Puri-Nethol; Purineantimetabolite: inhibits nucleic acid replication; Purinethol (TN); U-4748; Wellcome Brand of 6-Mercaptopurine; AG-670/31547064; Purine-6-thiol; Leukerin, 99%-Carc; Purine-6(1H)-thione; Purinethol, 6-mercaptopurine, 6-MP, Mercaptopurine; 1,7-Dihydro-6H-purine-6-thione; 1,9-dihydro-6H-purine-6-thione; 3,7-dihydropurine-6-thione; 3H-Purine-6-thiol; 6 MP; 6 Mercaptopurine; 6 Mercaptopurine Monohydrate; 6 Thiohypoxanthine; 6 Thiopurine; 6-MERCAPTOPURINE MONOHYDRATE; 6-MP; 6-Mercaptopurin; 6-Mercaptopurine; 6-Merkaptopurin; 6-Merkaptopurin [Czech]; 6-Purinethiol; 6-Thiohypoxanthine; 6-Thiopurine; 6-Thioxopurine; 7-Mercapto-1,3,4,6-tetrazaindene; 7H-purine-6-thiol; 9H-Purin-6-yl hydrosulfide; 9H-Purine-6(1H)-thione; Mercaptopurine (Purine analog)
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| Drug Type |
Small molecular drug
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| Therapeutic Class |
Anticancer Agents
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| Company |
Novopharm
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| Structure |
|
Download2D MOL |
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| Formula |
C5H4N4S
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| InChI |
InChI=1S/C5H4N4S/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)
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| InChIKey |
GLVAUDGFNGKCSF-UHFFFAOYSA-N
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| CAS Number |
CAS 50-44-2
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| PubChem Compound ID | |||||
| PubChem Substance ID |
4889, 5422, 538245, 602747, 3205553, 4912489, 5334583, 5370645, 6477910, 7366114, 7979906, 8136889, 8148223, 8149413, 9276666, 11335668, 11360907, 11363815, 11364775, 11366377, 11367337, 11368939, 11369899, 11371581, 11372939, 11374631, 11375499, 11377101, 11378064, 11446005, 11446674, 11461879, 11483955, 11487876, 11490307, 11492672, 11494735, 14772317, 15321640, 15970891, 16997018, 24882910, 25622685, 26611807, 26679290, 26748122, 26748123, 26748124, 31299583, 31665082
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| ChEBI ID |
ChEBI:50667
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| SuperDrug ATC ID |
L01BB02
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| SuperDrug CAS ID |
cas=000050442
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| Target and Pathway | |||||
| Target(s) | Inosine-5'-monophosphate dehydrogenase | Target Info | Inhibitor | [536724] | |
| DNA | Target Info | Breaker | [537146] | ||
| References | |||||
| Ref 537297 | S-adenosylmethionine regulates thiopurine methyltransferase activity and decreases 6-mercaptopurine cytotoxicity in MOLT lymphoblasts. Biochem Pharmacol. 2009 Jun 15;77(12):1845-53. Epub 2009 Mar 19. | ||||
| Ref 542241 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7226). | ||||
| Ref 536724 | Clinical pharmacology and pharmacogenetics of thiopurines. Eur J Clin Pharmacol. 2008 Aug;64(8):753-67. Epub 2008 May 28. | ||||
| Ref 537146 | 6-mercaptopurine (6-MP) induces p53-mediated apoptosis of neural progenitor cells in the developing fetal rodent brain. Neurotoxicol Teratol. 2009 Jul-Aug;31(4):198-202. Epub 2009 Mar 10. | ||||
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