Drug Information

Drug General Information
Drug ID
D04JPJ
Former ID
DAP000991
Drug Name
Lomustine
Synonyms
Belustine; CCNU; CINU; Cecenu; CeeNU; Chloroethylcyclohexylnitrosourea; Lomustina; Lomustinum; Bristol Myers Squibb Brand of Lomustine; CCNU [Chloroethyl nitrosoureas]; Cyclohexyl chloroethyl nitrosourea; Lomustine medac Brand; Medac Brand of Lomustine; Rhone Poulenc Rorer Brand of Lomustine; OR5087; RB 1509; SRI 2200; Bristol-Myers Squibb Brand of Lomustine; CeeNU (TN); Lomustina [INN-Spanish]; Lomustinum [INN-Latin]; NPFAPI-06; Rhone-Poulenc Rorer Brand of Lomustine; CeeNU, CCNU, Lomustine; Lomustine (USAN/INN); Lomustine [USAN:BAN:INN]; N-(2-Chloroethyl)-N'-cyclohexyl-N-nitrosourea; (Chloro-2-ethyl)-1-cyclohexyl-3-nitrosourea; (Cloro-2-etil)-1-cicloesil-3-nitrosourea; (Cloro-2-etil)-1-cicloesil-3-nitrosourea [Italian];1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea; 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea [Chloroethyl nitrosoureas]; 1-(2-Chloroethyl)-3-cyclohexylnitrosourea
Drug Type
Small molecular drug
Indication Brain cancer; Glioma [ICD9: 191, 225.0; ICD10:C71, D33] Approved [538491], [542229], [551871]
Therapeutic Class
Anticancer Agents
Structure
Download
2D MOL

3D MOL
Formula
C9H16ClN3O2
InChI
InChI=1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14)
InChIKey
GQYIWUVLTXOXAJ-UHFFFAOYSA-N
CAS Number
CAS 13010-47-4
PubChem Compound ID
3950
PubChem Substance ID
9290, 119147, 604677, 4964182, 7847429, 7979789, 8152480, 11446095, 11446868, 15121730, 29223064, 46506562, 48416181, 49854903, 50112720, 50177010, 53789456, 56313684, 57322064, 71821703, 81040920, 84941717, 92309013, 92710003, 103173774, 104253398, 104304994, 117664391, 118043410, 118049573, 124757517, 125164321, 125339834, 126533760, 126632297, 126658488, 126664336, 127993436, 131297250, 132048649, 134338261, 134989249, 135584134, 135692302, 136342506, 136375523, 136974470, 136999623, 137005631, 140170346
SuperDrug ATC ID
L01AD02
SuperDrug CAS ID
cas=013010474
Target and Pathway
Target(s) DNA Target Info Inhibitor [536461]
References
Ref 538491FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 017588.
Ref 542229(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7214).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536461Synthesis and evaluation of ethylnitrosoureas of substituted naphthalimides as anticancer compounds. Acta Pol Pharm. 2007 Jan-Feb;64(1):27-33.

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