Drug Information

Drug General Information
Drug ID
D0Z9NZ
Former ID
DAP001305
Drug Name
Glutethimide
Synonyms
Alfimid; Doriden; Dorimide; Elrodorm; Gimid; Glimid; Glutathimid; Glutethimid; Glutethimidum; Glutetimid; Glutetimida; Glutetimide; Glutetimidu; Gluthetimide; Noxiron; Noxyron; Ondasil; Rigenox; Sarodormin; Glutetimide [DCIT]; Glutetimidu [Polish]; CC 11511; LT00114358; Doriden (TN); Doriden-sed; Glutethimide [INN:BAN]; Glutethimidum [INN-Latin]; Glutetimida [INN-Spanish]; Glutethimide (JAN/INN); Phenyl-aethyl-glutarsaeureimid; Phenyl-aethyl-glutarsaeureimid [German]; Alpha-Ethyl-alpha-phenylglutarimide; Alpha-Phenyl-alpha-ethylglutaric acid imide; Alpha-Phenyl-alpha-ethylglutarimide; 2-Ethyl-2-phenylglutarimide; 2-Phenyl-2-ethylglutaric acid imide; 3-Ethyl-3-phenyl-2,6-diketopiperidine; 3-Ethyl-3-phenyl-2,6-dioxopiperidine; 3-Ethyl-3-phenyl-2,6-piperidinedione; 3-Phenyl-3-ethyl-2,6-diketopiperidine; 3-Phenyl-3-ethyl-2,6-dioxopiperidine; 3-ethyl-3-phenylpiperidine-2,6-dione
Drug Type
Small molecular drug
Indication Insomnia [ICD9: 307.41, 307.42, 327.0, 780.51, 780.52; ICD10:F51.0, G47.0] Approved [535773], [542204]
Therapeutic Class
Hypnotics and Sedatives
Structure
Download
2D MOL

3D MOL
Formula
C13H15NO2
InChI
InChI=1S/C13H15NO2/c1-2-13(10-6-4-3-5-7-10)9-8-11(15)14-12(13)16/h3-7H,2,8-9H2,1H3,(H,14,15,16)
InChIKey
JMBQKKAJIKAWKF-UHFFFAOYSA-N
CAS Number
CAS 77-21-4
PubChem Compound ID
3487
PubChem Substance ID
9692, 400159, 5047947, 7847598, 8152215, 10535494, 15414774, 26754495, 29215340, 29222619, 46506283, 48416061, 49973115, 53786842, 57321835, 78011658, 83568923, 92714692, 103304476, 104303656, 117423004, 124892162, 125357548, 126623946, 126679218, 128294734, 134338522, 134972155, 137141503, 137259869, 141622985, 144205194, 152037161, 160964704, 164831491, 170465223, 178103767, 179225784, 198993194, 223439844, 223681168, 226486312, 249990931, 250170659
SuperDrug ATC ID
N05CE01
SuperDrug CAS ID
cas=000077214
Target and Pathway
Target(s) Cytochrome P450 2D6 Target Info Inducer [536862], [537887]
KEGG Pathway Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Serotonergic synapse
Reactome Xenobiotics
WikiPathways Metapathway biotransformation
Tamoxifen metabolism
Oxidation by Cytochrome P450
Vitamin D Receptor Pathway
Aripiprazole Metabolic Pathway
Fatty Acid Omega Oxidation
Codeine and Morphine Metabolism
References
Ref 535773A comparison of the efficacy of aromatase inhibitors in second-line treatment of metastatic breast cancer. Am J Clin Oncol. 2003 Aug;26(4):S9-16.
Ref 542204(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7192).
Ref 536862A study of the effects of large doses of glutethimide that were used for self-poisoning during pregnancy on human fetuses. Toxicol Ind Health. 2008 Feb-Mar;24(1-2):69-78.
Ref 537887Neurosteroidogenesis in rat retinas. J Neurochem. 1994 Jul;63(1):86-96.

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