Drug Information

Drug General Information
Drug ID
D01UTL
Former ID
DAP001151
Drug Name
Desipramine
Synonyms
Demethylimipramine; Desimipramine; Desimpramine; Desipramin; Desipramina; Desipraminum; Desmethylimipramine; Dezipramine; Dimethylimipramine; Methylaminopropyliminodibenzyl; Monodemethylimipramine; Norimipramine; Norpramine; Pentofran; Pertrofane; Sertofran; Desipramine Hcl; DMI 50475; DMI (pharmaceutical); Desipramina [INN-Spanish]; Desipramine (D4); Desipramine (INN); Desipramine [INN:BAN]; Desipraminum [INN-Latin]; Norpramin (TN); Pertofrane (TN); ZERO/006017; N-(3-Methylaminopropyl)iminobibenzyl; (3-(10H,11H-Dibenzo[b,f]azepin-5-yl)propyl)methylamine; 10, 11-Dihydro-N-methyl-5H-dibez[b,f]azepine-5-propanamine; 10,11-Dihydro-5-(3-methylaminopropyl)-5H-dibenz(b,f)azepine; 3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE; 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methylpropan-1-amine; 5-(gamma-Methylaminopropyl)iminodibenzyl
Drug Type
Small molecular drug
Indication Depression; Attention deficit hyperactivity disorder [ICD9: 311, 314; ICD10:F30-F39, F90] Approved [536306], [539526], [551871]
Therapeutic Class
Antidepressants
Company
Sanofi Aventis Us Llc
Structure
Download
2D MOL

3D MOL
Formula
C18H22N2
InChI
InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3
InChIKey
HCYAFALTSJYZDH-UHFFFAOYSA-N
CAS Number
CAS 50-47-5
PubChem Compound ID
2995
PubChem Substance ID
9158, 647048, 3249345, 3727070, 5321893, 7737258, 7979043, 8151907, 10524411, 11111066, 11111067, 11335365, 11360604, 11363335, 11365897, 11368459, 11371457, 11374067, 11376621, 11461576, 11466371, 11467491, 11483778, 11486062, 11487907, 11490195, 11492129, 11494255, 14774838, 29214812, 29222144, 46504624, 47291013, 47291014, 47736341, 47736342, 47736343, 47959596, 48259094, 48259095, 48415856, 49698852, 49961473, 50100220, 50104283, 53787179, 57321547, 76076257, 85209781, 85753308
ChEBI ID
ChEBI:47781
SuperDrug ATC ID
N06AA01
SuperDrug CAS ID
cas=000050475
Target and Pathway
Target(s) Sodium-dependent noradrenaline transporter Target Info Inhibitor [537457]
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 536306Emerging treatments for depression. Expert Opin Pharmacother. 2006 Dec;7(17):2323-39.
Ref 539526(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2399).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 537457Augmentation effect of combination therapy of aripiprazole and antidepressants on forced swimming test in mice. Psychopharmacology (Berl). 2009 Jun 11.

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