Drug General Information
Drug ID
D01NJT
Former ID
DCL000526
Drug Name
Esreboxetine
Synonyms
Davedax; Norebox; Prolift; Reboxetine; Solvex; Vestra; Reboxetine [INN]; Reboxetine mesylate; Esreboxetine (USAN/INN); (+-)-(2R*)-2-((alphaR*)-alpha-(o-Ethoxyphenoxy)benzyl)morpholine; (2S)-2-[(S)-(2-ethoxyphenoxy)-phenylmethyl]morpholine; (S,S)-Reboxetine; (S,S)-reboxetine; 2-((2-ethoxyphenoxy)benzyl)morpholine methanesulfonate
Drug Type
Small molecular drug
Indication Fibromyalgia [ICD9: 729.1; ICD10:M79.7] Discontinued in Phase 2 [549540]
Company
Pfizer
Structure
Download
2D MOL

3D MOL

Formula
C19H23NO3
Canonical SMILES
CCOC1=CC=CC=C1OC(C2CNCCO2)C3=CC=CC=C3
InChI
1S/C19H23NO3/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18/h3-11,18-20H,2,12-14H2,1H3/t18-,19-/m0/s1
InChIKey
CBQGYUDMJHNJBX-OALUTQOASA-N
CAS Number
CAS 98769-81-4
PubChem Compound ID
PubChem Substance ID
SuperDrug ATC ID
N06AX18
Target and Pathway
Target(s) Sodium-dependent noradrenaline transporter Target Info Blocker [549974]
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 549540Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800040151)
Ref 549974Pfizer. Product Development Pipeline. March 31 2009.

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