Drug General Information
Drug ID	D0KS6W
Former ID	DNC005180
Drug Name	Phenyltoloxamine
Drug Type	Small molecular drug
Indication	Allergy [ICD9: 995.3; ICD10:T78.4]		Approved	[551871]
Structure		Download 2D MOL 3D MOL
Formula	C17H22ClNO
Canonical SMILES	CN(C)CCOC1=CC=CC=C1CC2=CC=CC=C2
InChI	1S/C17H21NO/c1-18(2)12-13-19-17-11-7-6-10-16(17)14-15-8-4-3-5-9-15/h3-11H,12-14H2,1-2H3
InChIKey	IZRPKIZLIFYYKR-UHFFFAOYSA-N
CAS Number	CAS 92-12-6
PubChem Compound ID	22528
Target and Pathway
Target(s)	Dopamine D1 receptor	Target Info	Inhibitor	[527160]
	D(4) dopamine receptor	Target Info	Inhibitor	[527160]
	D(2) dopamine receptor	Target Info	Inhibitor	[527160]
	D(1B) dopamine receptor	Target Info	Inhibitor	[527160]
KEGG Pathway	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Amphetamine addiction
	Morphine addiction
	Alcoholismhsa04080:Neuroactive ligand-receptor interaction
	Dopaminergic synapsehsa04015:Rap1 signaling pathway
	Alcoholismhsa04020:Calcium signaling pathway
PANTHER Pathway	Dopamine receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Dopamine receptor mediated signaling pathway
	Nicotine pharmacodynamics pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Nicotine pharmacodynamics pathwayP05912:Dopamine receptor mediated signaling pathway
PathWhiz Pathway	Dopamine Activation of Neurological Reward System
Reactome	Dopamine receptors
	G alpha (s) signalling eventsR-HSA-390651:Dopamine receptors
	G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
	G alpha (s) signalling events
WikiPathways	Hypothetical Network for Drug Addiction
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Genes and (Common) Pathways Underlying Drug Addiction
	GPCR ligand binding
	GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
	GPCR downstream signaling
	Nicotine Activity on Dopaminergic Neurons
	GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
	Nicotine Activity on Dopaminergic NeuronsWP58:Monoamine GPCRs
References
Ref 551871	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 527160	J Med Chem. 2004 Aug 12;47(17):4155-8.Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 receptor selectivity.

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