TTD | Drug: D0N8DP

Drug General Information
Drug ID	D0N8DP
Former ID	DIB002497
Drug Name	Bentazepam
Drug Type	Small molecular drug
Indication	Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42]		Approved	[551871]
Structure		Download 2D MOL 3D MOL
Formula	C17H16N2OS
Canonical SMILES	O=C1CN=C(c2ccccc2)c3c4CCCCc4sc3N1
InChI	1S/C17H16N2OS/c20-14-10-18-16(11-6-2-1-3-7-11)15-12-8-4-5-9-13(12)21-17(15)19-14/h1-3,6-7H,4-5,8-10H2,(H,19,20)
InChIKey	AIZFEOPQVZBNGH-UHFFFAOYSA-N
PubChem Compound ID	34592
Target and Pathway
Target(s)	GABA A receptor	Target Info	Modulator	[530960], [551871]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
	GABAergic synapse
	Morphine addiction
	Nicotine addiction
Reactome	Ligand-gated ion channel transport
Reactome	GABA A receptor activation
WikiPathways	SIDS Susceptibility Pathways
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transport
References
Ref 551871	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 530960	Prodynorphin gene deletion increased anxiety-like behaviours, impaired the anxiolytic effect of bromazepam and altered GABAA receptor subunits gene expression in the amygdala. J Psychopharmacol. 2011Jan;25(1):87-96.
Ref 551871	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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Drug Information