Drug Information

Drug General Information
Drug ID
D0P2IW
Former ID
DCL000286
Drug Name
Peramivir
Synonyms
BCZ; PeramiFlu; Rapiacta; BCX 1812; BCX1812; RWJ 270201; RWJ270201; BCX-1812; RWJ-270201; S-021812; (1S,2S,3S,4R)-3-(1-acetamido-2-ethylbutyl)-4-(diaminomethylideneamino)-2-hydroxycyclopentane-1-carboxylic acid; (1S,2S,3S,4R)-3-[(1S)-1-acetamido-2-ethylbutyl]-4-(diaminomethylideneamino)-2-hydroxycyclopentane-1-carboxylic acid; 3-(1'-acetylamino-2'-ethyl)butyl-4-((aminoimino)methyl)amino-2-hydroxycyclopentane-1-carboxylic acid; 3-(1-ACETYLAMINO-2-ETHYL-BUTYL)-4-GUANIDINO-2-HYDROXY-CYCLOPENTANECARBOXYLIC ACID; PRV
Drug Type
Small molecular drug
Indication Influenza virus [ICD10:J11.1] Approved [533123]
Company
BioCryst Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C15H28N4O4
Canonical SMILES
CCC(CC)C(C1C(CC(C1O)C(=O)O)N=C(N)N)NC(=O)C
InChI
1S/C15H28N4O4/c1-4-8(5-2)12(18-7(3)20)11-10(19-15(16)17)6-9(13(11)21)14(22)23/h8-13,21H,4-6H2,1-3H3,(H,18,20)(H,22,23)(H4,16,17,19)/t9-,10+,11+,12?,13+/m0/s1
InChIKey
XRQDFNLINLXZLB-GKWMMFDUSA-N
CAS Number
CAS 229614-55-5
PubChem Compound ID
151164
PubChem Substance ID
14777381, 14875127, 22429355, 46227731, 50209836, 57347304, 99431958, 103990339, 104430335, 126666898, 137249360, 138238553, 138364215, 138571744, 152063968, 163437389, 175427078, 175438363, 185972132, 196408590, 223665005, 223667970, 226474782, 244218557, 252216025
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) Neuraminidase Target Info Inhibitor [536654], [536970]
KEGG Pathway Other glycan degradation
References
Ref 5331232014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
Ref 536654Current and future antiviral therapy of severe seasonal and avian influenza. Antiviral Res. 2008 Apr;78(1):91-102. Epub 2008 Feb 4.
Ref 536970Developing new antiviral agents for influenza treatment: what does the future hold? Clin Infect Dis. 2009 Jan 1;48 Suppl 1:S3-13.

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