Drug Information

Drug General Information
Drug ID
D02STN
Former ID
DNC003575
Drug Name
ABIRATERONE
Synonyms
Abiraterone (AR inhibitor)
Drug Type
Small molecular drug
Indication Metastatic castration-resistant prostate cancer [ICD9: 140-229, 185; ICD10:C61] Approved [527863], [531783], [541843]
Structure
Download
2D MOL

3D MOL
Formula
C24H31NO
InChI
InChI=1S/C24H31NO/c1-23-11-9-18(26)14-17(23)5-6-19-21-8-7-20(16-4-3-13-25-15-16)24(21,2)12-10-22(19)23/h3-5,7,13,15,18-19,21-22,26H,6,8-12,14H2,1-2H3/t18-,19-,21-,22-,23-,24+/m0/s1
InChIKey
GZOSMCIZMLWJML-VJLLXTKPSA-N
CAS Number
CAS 154229-19-3
PubChem Compound ID
132971
PubChem Substance ID
10243249, 14925329, 29310988, 51070382, 56412748, 57344329, 85160750, 99436993, 103559525, 104378672, 109693725, 118842183, 124757018, 125092124, 125163822, 126647604, 126666776, 126731192, 128029089, 131408327, 134340780, 135089190, 136340288, 137172988, 137213544, 143493380, 152236442, 152258876, 152344306, 160645799, 160647725, 160826036, 162011587, 162037451, 162201747, 163092693, 163388487, 164045167, 164194062, 164831353, 165245562, 170507595, 172912741, 174527616, 175268637, 175427038, 175437823, 176484827, 178103356, 179692447
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) 17 alpha-hydroxylase-C17, 20-lyase Target Info Modulator [527863], [531783]
BioCyc Pathway Superpathway of steroid hormone biosynthesis
Glucocorticoid biosynthesis
Androgen biosynthesis
KEGG Pathway Steroid hormone biosynthesis
Metabolic pathways
Ovarian steroidogenesis
Prolactin signaling pathway
PathWhiz Pathway Androgen and Estrogen Metabolism
Steroidogenesis
Reactome Androgen biosynthesis
Glucocorticoid biosynthesis
Endogenous sterols
WikiPathways Metapathway biotransformation
Steroid Biosynthesis
Oxidation by Cytochrome P450
Metabolism of steroid hormones and vitamin D
Glucocorticoid & Mineralcorticoid Metabolism
Prostate Cancer
Phase 1 - Functionalization of compounds
References
Ref 527863Selective blockade of androgenic steroid synthesis by novel lyase inhibitors as a therapeutic strategy for treating metastatic prostate cancer. BJU Int. 2005 Dec;96(9):1241-6.
Ref 5317832011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
Ref 541843(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6745).
Ref 527863Selective blockade of androgenic steroid synthesis by novel lyase inhibitors as a therapeutic strategy for treating metastatic prostate cancer. BJU Int. 2005 Dec;96(9):1241-6.
Ref 5317832011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.

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