Drug Information

Drug General Information
Drug ID
D0X6BV
Former ID
DCL001036
Drug Name
Vilazodone
Synonyms
Vilazodone [INN]; Vilazodone (TN); 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl]-1-benzofuran-2-carboxamide; 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl]benzofuran-2-carboxamide
Drug Type
Small molecular drug
Indication Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32] Approved [531783], [542450]
Company
Genaissance and Merck KGaA
Structure
Download
2D MOL

3D MOL
Formula
C26H27N5O2
InChI
InChI=1S/C26H27N5O2/c27-16-18-4-6-23-22(13-18)19(17-29-23)3-1-2-8-30-9-11-31(12-10-30)21-5-7-24-20(14-21)15-25(33-24)26(28)32/h4-7,13-15,17,29H,1-3,8-12H2,(H2,28,32)
InChIKey
SGEGOXDYSFKCPT-UHFFFAOYSA-N
CAS Number
CAS 163521-12-8
PubChem Compound ID
6918314
PubChem Substance ID
14930538, 23950818, 43529694, 76910791, 85210119, 93300539, 103455044, 104040116, 114787770, 124490438, 126681745, 129231444, 134339460, 135270095, 137083322, 137188808, 141233041, 152064163, 152258562, 160645967, 160647397, 160831434, 162011476, 162224429, 163094960, 163392752, 164045358, 164766116, 170501384, 172914663, 175268384, 175427083, 178103999, 186005325, 198993119, 204388973, 223393050, 223536020, 223660986, 224093528, 226949401, 242060090, 246074631, 249863492, 251875390, 251916863, 251918102, 251971270, 252067762, 252091522
SuperDrug ATC ID
N06AX24
Target and Pathway
Target(s) Sodium-dependent serotonin transporter Target Info Modulator [531783]
5-hydroxytryptamine 1A receptor Target Info Modulator [531783]
KEGG Pathway Serotonergic synapsehsa04024:cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway 5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Monoamine Transport
SIDS Susceptibility Pathways
NRF2 pathway
Synaptic Vesicle Pathway
Serotonin Transporter ActivityWP722:Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 5317832011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
Ref 542450(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7427).
Ref 5317832011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.

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