Drug Information

Drug General Information
Drug ID
D0O3FG
Former ID
DCL000768
Drug Name
Desvenlafaxine
Synonyms
Norvenlafaxine; DVS 233; Desvenlafaxine (INN); Desvenlafaxine [INN:BAN]; O-Desmethylvenlafaxine; WY 45,233;O-DESMETHYLVENLAFAXINE (ODV); WY-45,233; 4-(2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenol; 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol
Drug Type
Small molecular drug
Indication Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32] Approved [529941], [542166]
Major depressive disorder; Menopausal staging; Vasomotor symptoms [ICD9: 296, 296.2, 296.3, 627.2; ICD10:F30-F39, F32, F33, N95.0, N95.1] Phase 3 [536580], [542166]
Company
Wyeth
Structure
Download
2D MOL

3D MOL
Formula
C16H25NO2
InChI
InChI=1S/C16H25NO2/c1-17(2)12-15(13-6-8-14(18)9-7-13)16(19)10-4-3-5-11-16/h6-9,15,18-19H,3-5,10-12H2,1-2H3
InChIKey
KYYIDSXMWOZKMP-UHFFFAOYSA-N
CAS Number
CAS 93413-62-8
PubChem Compound ID
125017
PubChem Substance ID
6721883, 10241237, 14872425, 29304940, 47731323, 47805623, 50065397, 80821498, 91612302, 92729724, 96024490, 99246116, 99443254, 103313826, 103923621, 104360436, 118842251, 125359943, 128454905, 131330684, 134339254, 134339255, 135080249, 135684170, 136352797, 136375566, 137206387, 142340945, 152035730, 160967870, 162140123, 162201456, 162312738, 163123297, 164178123, 164828303, 174477381, 175423896, 178103733, 179293788, 184536742, 185989359, 198991666, 203355733, 204362541, 210279762, 210282085, 223381758, 223448271, 223704725
SuperDrug ATC ID
N06AX23
Target and Pathway
Target(s) Sodium-dependent serotonin transporter Target Info Modulator [529941]
KEGG Pathway Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway 5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathway
WikiPathways Monoamine Transport
SIDS Susceptibility Pathways
NRF2 pathway
Synaptic Vesicle Pathway
Serotonin Transporter Activity
References
Ref 5299412008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.
Ref 536580Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2.
Ref 542166(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7158).
Ref 5299412008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.

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