Drug Information

Drug General Information
Drug ID
D03HYQ
Former ID
DAP000875
Drug Name
Ranolazine
Synonyms
Latixa; Ranexa; RAN D; Ranolazine dihydrochloride; Ran4; Ranolazine 2HCl; CVT-303; KEG-1295; RS-43285; Ranexa (TN); Ranexa, Ranolazine; RS-43285-003; Ranolazine (USAN/INN); N-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide; (-)-Ranolazine
Drug Type
Small molecular drug
Indication Chronic angina [ICD9: 413; ICD10:I20] Approved [528253], [528715], [542312]
Therapeutic Class
Analgesics
Company
CV Therapeutics
Structure
Download
2D MOL

3D MOL
Formula
C24H33N3O4
InChI
InChI=1S/C24H33N3O4/c1-18-7-6-8-19(2)24(18)25-23(29)16-27-13-11-26(12-14-27)15-20(28)17-31-22-10-5-4-9-21(22)30-3/h4-10,20,28H,11-17H2,1-3H3,(H,25,29)
InChIKey
XKLMZUWKNUAPSZ-UHFFFAOYSA-N
CAS Number
CAS 142387-99-3
PubChem Compound ID
56959
PubChem Substance ID
7980486, 8184974, 12013498, 14856376, 26612929, 26749060, 26749061, 43114706, 46505145, 47207361, 47795040, 48169373, 50070803, 50107515, 51004683, 56463697, 57313861, 81040983, 85171832, 85789241, 90340842, 92124680, 92307911, 92309225, 92712119, 103482101, 104171232, 104253386, 104311416, 117573069, 121363701, 124750209, 124757504, 124799345, 124881338, 124881339, 125164308, 125360240, 126583887, 126622101, 126630205, 126656915, 126666839, 126724363, 129701807, 134338152, 135015431, 135684171, 135692283, 136375567
SuperDrug ATC ID
C01EB18
Target and Pathway
Target(s) Plasminogen Target Info Modulator [532368]
KEGG Pathway Neuroactive ligand-receptor interaction
Complement and coagulation cascades
Staphylococcus aureus infection
Influenza A
PANTHER Pathway Blood coagulation
Plasminogen activating cascade
Pathway Interaction Database Angiopoietin receptor Tie2-mediated signaling
p75(NTR)-mediated signaling
amb2 Integrin signaling
Syndecan-4-mediated signaling events
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
PathWhiz Pathway Coagulation
Reactome Platelet degranulation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Dissolution of Fibrin Clot
WikiPathways Complement and Coagulation Cascades
Human Complement System
Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Activation of Matrix Metalloproteinases
Blood Clotting Cascade
Dissolution of Fibrin Clot
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 528253Late sodium current in the pathophysiology of cardiovascular disease: consequences of sodium-calcium overload. Heart. 2006 Jul;92 Suppl 4:iv1-iv5.
Ref 5287152006 drug approvals: finding the niche. Nat Rev Drug Discov. 2007 Feb;6(2):99-101.
Ref 542312(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7291).
Ref 532368Tranexamic acid in trauma: how should we use it. J Trauma Acute Care Surg. 2013 Jun;74(6):1575-86.

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