Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0P8PH
|
||||
| Former ID |
DIB021234
|
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| Drug Name |
XE991
|
||||
| Synonyms |
LS-190926
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [539673] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C26H20N2O
|
||||
| InChI |
InChI=1S/C26H20N2O/c29-25-21-5-1-3-7-23(21)26(17-19-9-13-27-14-10-19,18-20-11-15-28-16-12-20)24-8-4-2-6-22(24)25/h1-16H,17-18H2
|
||||
| InChIKey |
KHJFBUUFMUBONL-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Kv7.5 | Target Info | Blocker (channel blocker) | [525770] | |
| Potassium voltage-gated channel subfamily KQT member 4 | Target Info | Blocker (channel blocker) | [525999] | ||
| Potassium voltage-gated channel subfamily KQT member 1 | Target Info | Blocker (channel blocker) | [525778] | ||
| Potassium voltage-gated channel subfamily KQT member 2 | Target Info | Blocker (channel blocker) | [534766] | ||
| PANTHER Pathway | Muscarinic acetylcholine receptor 1 and 3 signaling pathway | ||||
| PathWhiz Pathway | Muscle/Heart Contraction | ||||
| References | |||||
| Ref 525770 | KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents. J Biol Chem. 2000 Aug 4;275(31):24089-95. | ||||
| Ref 525778 | Molecular basis for differential sensitivity of KCNQ and I(Ks) channels to the cognitive enhancer XE991. Mol Pharmacol. 2000 Jun;57(6):1218-23. | ||||
| Ref 525999 | KCNQ4 channels expressed in mammalian cells: functional characteristics and pharmacology. Am J Physiol Cell Physiol. 2001 Apr;280(4):C859-66. | ||||
| Ref 534766 | KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science. 1998 Dec 4;282(5395):1890-3. | ||||
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